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Gangliosides are shed by tumor cells and can bind to normal cells in the tumor microenvironment and affect their function. Exposure of fibroblasts to exogenous gangliosides increases epidermal growth factor (EGF)-induced fibroblast proliferation and enhances EGF receptor (EGFR)-mediated activation of the mitogen-activated protein kinase signaling pathway(More)
Skeletonema costatum and Prorocentrum dentatum are the two common HAB species in East China Sea, and Prorocentrum is more responsible for most HAB events in Spring since late 90's. The HAB caused by Skeletonema usually occurs from June to August. However, these two species will not bloom at the same time. Two mesocosm experiments were conducted in East(More)
MEB4 murine melanoma cells synthesize G(M3) as the major ganglioside. Inhibition of G(M3) synthesis by a specific glucosylceramide synthase inhibitor resulted in reduced tumorigenicity and metastatic potential of these cells. We used a molecular approach--antisense transfection targeting the glucosylceramide synthase gene--to regulate glycosphingolipid(More)
Shedding of neuroblastoma gangliosides is positively correlated with tumour progression in patients with neuroblastoma. In assessing the biological activity of these ganglioside molecules, we recently found that total human neuroblastoma gangliosides inhibit cellular immune responses. Here, we have studied the major neuroblastoma ganglioside, GD2. GD2 was(More)
Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were formulated in(More)
Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from(More)
Although significant progress has been achieved, effective oral delivery of protein drugs such as insulin by nanoparticle-based carrier systems still faces certain formidable challenges. Considerable amount of protein drug is released from the nanoparticles (NPs) in the gastrointestinal (GI) tract. Because of their low permeability through the intestinal(More)
In order to detect the relationships of human laryngeal squamous cell carcinoma (LSCC) with the expression of Vascular Endothelial Growth Factor C (VEGF-C) and Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3), we examined the level of VEGF-C and VEGFR-3 gene expression in the samples from 30 cases of normal laryngeal mucosa tissue (NLM), primary(More)
A key to 1 Japanese and 18 Chinese species of the Pegomya acklandi group, including 1 new species, is given below: 1(4) Apical border of the lateral lobe of 5th sternite with an angular notch. 2(3) Hairs on the basal part of surstylus rather thick and numerous; inner side of the twig of surstylus with a tubercle; apex of postgonite hook-like. ... Pegomya(More)
1. Eutrichota (Parapegomyia) tuberifolia Deng, Fan et Li, sp. nov. Male: Body length 6mm. The new species is related to Eutrichota (Parapegomyia) socculata Zett., 1938, both with the posterior lobe of pregonites well extended. But the former differs from the latter by the expanded fore part of posterior twig of pregonite and a deep concaving on anterior(More)