Ruixiang Li

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Gangliosides are shed by tumor cells and can bind to normal cells in the tumor microenvironment and affect their function. Exposure of fibroblasts to exogenous gangliosides increases epidermal growth factor (EGF)-induced fibroblast proliferation and enhances EGF receptor (EGFR)-mediated activation of the mitogen-activated protein kinase signaling pathway(More)
MEB4 murine melanoma cells synthesize G(M3) as the major ganglioside. Inhibition of G(M3) synthesis by a specific glucosylceramide synthase inhibitor resulted in reduced tumorigenicity and metastatic potential of these cells. We used a molecular approach--antisense transfection targeting the glucosylceramide synthase gene--to regulate glycosphingolipid(More)
Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were formulated in(More)
  • R Li, A Deng
  • 1990
A key to 1 Japanese and 18 Chinese species of the Pegomya acklandi group, including 1 new species, is given below: 1(4) Apical border of the lateral lobe of 5th sternite with an angular notch. 2(3) Hairs on the basal part of surstylus rather thick and numerous; inner side of the twig of surstylus with a tubercle; apex of postgonite hook-like. ... Pegomya(More)
Although significant progress has been achieved, effective oral delivery of protein drugs such as insulin by nanoparticle-based carrier systems still faces certain formidable challenges. Considerable amount of protein drug is released from the nanoparticles (NPs) in the gastrointestinal (GI) tract. Because of their low permeability through the intestinal(More)
Prorocentrum donghaiense caused large-scale red tides off Chinese coast in recent years. Expressed sequence tag (EST) analysis was carried out for this dinoflagellate in order to identify the genes involved in its proliferation and death. A cDNA library was constructed for P. donghaiense at late exponential growth phase, and 308 groups of EST were(More)
Skeletonema costatum and Prorocentrum dentatum are the two common HAB species in East China Sea, and Prorocentrum is more responsible for most HAB events in Spring since late 90's. The HAB caused by Skeletonema usually occurs from June to August. However, these two species will not bloom at the same time. Two mesocosm experiments were conducted in East(More)
OBJECTIVE To understand the regulation of chondrocyte proliferation in callus. METHODS The histological structure of callus was observed and the percent of positive cells of Cylin D3, Cyclin E, Cyclin A, PCNA and BrdU in callus of 20 male SD rats were caculated in the fracture healing model by HE staining and immunohistochemical staining at 1, 2, 3 and 4(More)