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MEB4 murine melanoma cells synthesize G(M3) as the major ganglioside. Inhibition of G(M3) synthesis by a specific glucosylceramide synthase inhibitor resulted in reduced tumorigenicity and metastatic potential of these cells. We used a molecular approach--antisense transfection targeting the glucosylceramide synthase gene--to regulate glycosphingolipid(More)
The single crystal 6H-SiC with [0001] crystal direction irradiated by 400 keV He + ions with 1 × 10 17 ions/cm 2 fluence at 400 • C were annealed at 600, 900, 1200 and 1400 • C for different durations. The evolution of helium bubbles and discs was investigated by transmission electron microscopy. An irradiated layer distributed with fine helium bubbles was(More)
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