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The direct detection of neuronal electrical activity is one of the most challenging goals in non-BOLD fMRI research. Previous work has demonstrated its feasibility in phantom and cell culture studies, but attempts in in vivo studies remain few and far between. Most recent in vivo studies used T2*-weighted sequences to directly detect neuronal electrical(More)
Blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), one of the most powerful technologies in neuroscience, measures neural activity indirectly. Therefore, systematic correlation of BOLD signals with other neural activity measurements is critical to understanding and then using the technology. Numerous studies have revealed(More)
The neural activities of the olfactory bulb (OB) can be modulated significantly by internal brain states. While blood oxygenation level dependent functional MRI (BOLD-fMRI) has been extensively applied to study OB in small animals, the relationship between BOLD signals and electrophysiological signals remains to be elucidated. Our recent study has revealed(More)
The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered mechanisms. We found that(More)
Functional MRI (fMRI) has evolved from simple observations of regional changes in MRI signals caused by cortical activity induced by a task or stimulus, to task-free acquisitions of images in a resting state. Such resting state signals contain low frequency fluctuations which may be correlated between voxels, and strongly correlated regions are deemed to(More)
Reactivation of deafferented cortex plays a key role in mediating the recovery of lost functions, although the precise mechanism is not fully understood. This study simultaneously characterized the dynamic spatiotemporal features of tactile responses in areas 3b and 1 before and 6-8 weeks after partial dorsal column lesion (DCL), and examined how the(More)
To compose some happy melodies which have hierarchical structures, this paper proposes an automatic melody composition algorithm based on relations. First, various types of melody structure are formalized and saved into a database, so the melody structure form preferred by a user can be elected by human-computer interaction. Second, some sequences of(More)
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