Ruilian Xie

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Lin28B is a RNA-binding protein that inhibits the let-7 microRNA family and acts as an oncogene in various human malignant diseases. Conversely, the members of let-7 family function as tumor suppressers and are often inactivated in cancers. The interaction of Lin28B/let-7 plays a crucial part of tumorigenesis. In this study, the authors examined the Lin28B(More)
The expression of miRNA influencing the pathogenesis of OS have been reported previously, however, different samples selection and sequencing platforms made obvious differences in miRNA expression analysis. We aim to identify reliable prognostic and treatment biomarkers for OS by systematic analysis of miRNAs expression data sets from biased data set. Seven(More)
The aim of this study was to comprehensively evaluate via a meta-analysis the association between p27 expression and clinical outcome in breast cancer patients. We conducted a meta-analysis of 20 studies (n= 6463 patients) that evaluated the correlation between p27 expression and indicators of breast cancer clinical outcome, including overall survival (OS),(More)
To understand the transcriptional regulation of p73 by promoter methylation and Nrf-2 in breast carcinogenesis, ChIP assay indicated that Nrf-2 can bind to both promoters and can activate the transcription of TAp73 and ΔNp73 in MCF-7 cell line, knockdown of Nrf-2 gene resulted in an abrogation of TAp73 and ΔNp73 expression in the cells transfected with(More)
The current study aimed to investigate the effects of p16 hypermethylation on breast cancer quantitatively through a meta-analysis of available case-control studies (including malignant, benign and normal breast cancer tissues). The PubMed, Web of Science and EBSCO databases were searched from their inceptions to February 1, 2012. Crude odds ratios (ORs)(More)
BACKGROUND The protein p27 (p27(Kip1)) is a member of the cyclin-dependent kinase inhibitor family, which negatively regulates cell cycle progression, and the phosphorylation of p27 has been proven to affect its stability and nuclear export. Clinical studies on the relation between p27 and phosphorylated p27 (p-p27Ser10) in breast invasive ductal carcinomas(More)
Many fault-tolerant routing algorithms for Network-on-Chip (NoC) are developed to overcome faulty components and provide reliable transmission. However, few works have considered the traffic load around the faulty region. To solve this problem, this paper presents a Fault-Tolerant Odd–Even (FTOE) turn model and Load-Balancing Fault-Tolerant (LBFT) routing(More)
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