Ruijin Dua

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Herb-drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction accuracy of potential herb-drug interactions using the semipurified milk thistle preparation, silibinin, as an exemplar herbal product. Interactions between silibinin constituents and the probe substrates warfarin(More)
• The robustness of clustered networks with partial support–dependence relations is studied by adopting two attack strategies. • The first order region becomes smaller as average degree or clustering coefficient increases. • The second order region becomes larger as average degree or clustering coefficient increases. • Clustering coefficient has a(More)
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