Ruiji Zhen

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OBJECTIVE Since histone hypoacetylation due to excess histone deacetylases (HDACs) has been associated with transcriptional repression in leukemia, we aimed to determine deficient histone acetylation in patients with acute leukemia and the effect of its correction by an isothiocyanate. METHODS The acetylation status of histones H3 and H4 in cells from(More)
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