Ruifang Guo

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Statistical methods have proven invaluable tools for enhancing the quality of microarray analysis. In this study, we used different methods such as significance analysis of microarrays (SAM) and Bayesian analysis of gene expression levels (BAGEL), to analyze the same set of raw data in an attempt to maximize the chance of identifying genes whose expression(More)
Both the ventral and dorsal visual streams in the human brain are known to be involved in reading. However, the interaction of these two pathways and their responses to different cognitive demands remains unclear. In this study, activation of neural pathways during Chinese character reading was acquired by using a functional magnetic resonance imaging(More)
The world’s largest dam—the Three Gorges Dam (TGD)—has been in operation for more than 10 years. While the recent shrinkage of large lakes and increased severe droughts in the downstream have been subjectively ascribed to TGD, empirical support based on thorough analysis is still lacking, leaving a gap for ecologists to quantify the TGD impacts on the(More)
Rain gauge and satellite-retrieved data have been widely used in basin-scale hydrological applications. While rain gauges provide accurate measurements that are generally unevenly distributed in space, satellites offer spatially regular observations and common error prone retrieval. Comparative evaluation of gauge-based and satellite-based data is necessary(More)
Gastric cancer (GC) is one of the most frequent malignant tumors. In order to systematically characterize the cellular and molecular mechanisms of intestinal GC development, in this study, we used 22K oligonucleotide microarrays and bioinformatics analysis to evaluate the gene expression profiles of GC in 45 tissue samples, including 20 intestinal GC tissue(More)
OBJECTIVES Hepatocellular carcinoma (HCC) is receiving increased attention. This study was designed to investigate the effect of selective Cyclooxygenase-2 (COX-2) inhibitor, nimesulide, on the expression of Smad4 in human hepatocellular carcinoma HepG2. MATERIALS AND METHODS HepG2 cells were incubated in various concentrations of nimesulide (25, 50, 100,(More)
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