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The ubiquitin pathway targets proteins for degradation through the post-translational covalent attachment of the 76 amino acid protein ubiquitin to epsilon-amino lysyl groups on substrate proteins. Two instability determinants recognized by the ubiquitin pathway in Saccharomyces cerevisiae have been identified. One is described by the N-end rule and(More)
A general method for purification of any substrate of the ubiquitin pathway, the major eukaryotic proteolytic pathway, should utilize the common characteristic of covalent linkage of ubiquitin to substrate lysyl residues. The utility of a N-terminal histidine-tagged ubiquitin (HisUb) for in vivo conjugation and isolation of ubiquitinated proteins by metal(More)
OBJECTIVE To study the main risk factors of low back pain of workers ina foundry factory of the automobile company using cross sectional epidemiological investigation, and to provide scientific base for preventing the disorder. METHODS The low back pain and work loads of 1340 workers in a foundry factory of the automobile company were investigated using(More)
OBJECTIVE To analyze the prevalence and risk factors of multiple musculoskeletal disorders (MSDs) in auto workers and the associations between MSDs at different sites. METHODS A cross-sectional survey was conducted in 3998 workers, who were selected from a Chinese auto corporation by cluster random sampling, using the revised Nordic MSDs standard(More)
SUMMARY Rats bearing transplantable thyroid tumors representing two different stages of progression were used to study the incorporation of '3 ' I into monoiodotyrosine, diiodotyrosine, diiodothyronine, triiodothyronine, and thyroxine by the host thyroid glands and the tumors. The tissues were simultaneously used for assaying iodide peroxidase activity.(More)
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