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Current advances in molecular biology enable us to access the rapidly increasing body of genetic information. It is still challenging to model gene systems at the molecular level. Here, we propose two types of reaction kinetic models for constructing genetic networks. Time delays involved in transcription and translation are explicitly considered to explore(More)
A stochastic genetic toggle switch model that consists of two identical, mutually repressive genes is built using the Gillespie algorithm with time delays as an example of a simple stochastic gene regulatory network. The stochastic kinetics of this model is investigated, and it is found that the delays for the protein productions can highly weaken the(More)
The problem of secure distributed storage systems (DSS) with regenerating codes is concerned in this paper. We consider an eavesdropper model where an eavesdropper wiretaps a subset of storage nodes, and either their repairing data or stored data can be wiretapped. We focus on two typical and special cases, the Minimum Bandwidth Repair (MBR) and the Minimum(More)
A microstructure design of anisotropic resonant inclusions is investigated for the elastic metamaterial plate with the aid of the numerically based effective medium model. Experimental validation is then conducted in the anisotropic metamaterial plate through both harmonic and transient wave testing, from which the anisotropic effective dynamic mass(More)
Substantial pharmacological evidence in vitro and in vivo has suggested the existence of subtypes of the kappa opioid receptor. Quantitative radioligand binding techniques resolved the presence of two high affinity binding sites for the kappa 1 ligand [3H]U69,593 in mouse brain membranes, termed kappa 1a and kappa 1b, respectively. Whereas the kappa 1a site(More)
To study noise in the number of protein molecules produced in gene expression, we use a delayed reaction model coupling transcription and translation to examine nine biochemical factors. Fourteen numerical experiments were performed, which show clearly the linear scaling behavior between the protein variance and the mean. We found that the most dominant(More)
BACKGROUND The RNA binding protein, DEAD END (DND1), is essential for maintaining viable germ cells in vertebrates. It is also a testicular germ cell tumor susceptibility factor in mice. DND1 has been shown to interact with the 3'-untranslated region (3'-UTR) of mRNAs such as P27 and LATS2. Binding of DND1 to the 3'-UTRs of these transcripts blocks the(More)
Blue luminescent reduced state carbon dots were prepared by reducing carbon dots with NaBH(4). The quantum yield of the reduced state carbon dots increased from 2% to 24% and the maximum emission wavelength shifted from 520 to 450 nm. This offers a simple pathway to enhance the luminescence of carbon dots.