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In this article, we present an efficient B<sup>&plus;</sup>-tree based indexing method, called iDistance, for K-nearest neighbor (KNN) search in a high-dimensional metric space. iDistance partitions the data based on a space- or data-partitioning strategy, and selects a reference point for each partition. The data points in each partition are transformed(More)
BACKGROUND The Notch signaling pathway regulates adult neurogenesis under physiological and pathophysiological conditions. MicroRNAs are small non-coding RNA molecules that regulate gene expression. The present study investigated the effect of miR-124a on the Notch signaling pathway in stroke-induced neurogenesis. METHODOLOGY AND PRINCIPAL FINDINGS We(More)
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding(More)
The moving k nearest neighbor (MkNN) query finds the k nearest neighbors of a moving query point continuously. The high potential of reducing the query processing cost as well as the large spectrum of associated applications have attracted considerable attention to this query type from the database community. This paper presents an incremental(More)
BACKGROUND AND PURPOSE Advanced age is associated with a decrease in brain plasticity compared with the young adult. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor promotes brain plasticity and improves functional outcome after stroke in the young animal. Here, we test the hypothesis that sildenafil provides restorative therapeutic benefit to the(More)
Destination prediction is an essential task for many emerging location based applications such as recommending sightseeing places and targeted advertising based on destination. A common approach to destination prediction is to derive the probability of a location being the destination based on historical trajectories. However, existing techniques using this(More)
Massive Open Online Courses (MOOCs) have received widespread attention for their potential to scale higher education, with multiple platforms such as Coursera, edX and Udacity recently appearing. Despite their successes , a major problem faced by MOOCs is low completion rates. In this paper, we explore the accurate early identification of students who are(More)
This article reviews current data on the induction of neurogenesis after stroke in the adult brain. The discussion of neurogenesis is divided into production, migration, and survival of these newly formed cells. For production, the subpopulations and the types of cell division are presented. Discussion of cell migration entails presenting data on both the(More)
Sildenafil, a type 5 phosphodiesterase isoenzyme (PDE5) inhibitor with a short half-life, increases brain cyclic guanosine monophosphate (cGMP) levels and improves neurological functional recovery when administered after stroke. In the present study, we investigated the effects of tadalafil (Cialis), a long acting PDE5 inhibitor, on brain cGMP levels,(More)