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Juan A. Vizcaíno1,17, Eric W. Deutsch2,17, Rui Wang1, Attila Csordas1, Florian Reisinger1, Daniel Ríos1, José A. Dianes1, Zhi Sun2, Terry Farrah2, Nuno Bandeira3, Pierre-Alain Binz4, Ioannis Xenarios4,5,6, Martin Eisenacher7, Gerhard Mayer7, Laurent Gatto8, Alex Campos9, Robert J. Chalkley10, Hans-Joachim Kraus11, Juan Pablo Albar12, Salvador(More)
This paper presents an optimal economic dispatch for power plants by using modified particle swarm optimization (PSO) algorithm. The economic dispatch problem in power systems is to determine the optimal combination of power outputs for all generating units in order that the total fuel cost can be minimized, furthermore, all practical constraints can be(More)
The PRoteomics IDEntifications (PRIDE, http://www.ebi.ac.uk/pride) database at the European Bioinformatics Institute is one of the most prominent data repositories of mass spectrometry (MS)-based proteomics data. Here, we summarize recent developments in the PRIDE database and related tools. First, we provide up-to-date statistics in data content, splitting(More)
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine gamma-lyase(More)
The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H(2)S had only been known for its toxicity and environmental hazard. Physiological importance of H(2)S has been appreciated for about a decade. It started by the discovery of(More)
The PRoteomics IDEntifications (PRIDE) database is one of the world-leading data repositories of mass spectrometry (MS)-based proteomics data. Since the beginning of 2014, PRIDE Archive (http://www.ebi.ac.uk/pride/archive/) is the new PRIDE archival system, replacing the original PRIDE database. Here we summarize the developments in PRIDE resources and(More)
Users' locations are important to many applications such as targeted advertisement and news recommendation. In this paper, we focus on the problem of profiling users' home locations in the context of social network (Twitter). The problem is nontrivial, because signals, which may help to identify a user's location, are scarce and noisy. We propose a unified(More)
Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and(More)
Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many liver proteins, including actin, tubulin, and(More)
Accumulating evidence has shown that dysfunctional mitochondria can be selectively removed by mitophagy. Dysregulation of mitophagy is implicated in the development of neurodegenerative disease and metabolic disorders. How individual mitochondria are recognized for removal and how this process is regulated remain poorly understood. Here we report that(More)