Rui L. Lopes

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E-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations represent a clinical burden, due to the uncertainty of their pathogenic role. In vitro and in vivo, most mutations lead to loss-of-function,(More)
Evolutionary Algorithms (EA) approach the genotype–phenotype relationship differently than does nature, and this discrepancy is a recurrent issue among researchers. Moreover, in spite of some performance improvements, it is a fact that biological knowledge has advanced faster than our ability to incorporate novel biological ideas into EAs. Recently, some(More)
The relationship between the genotype and the phenotype in Evolutionary Algorithms (EA) is a recurrent issue among researchers. Based on our current understanding of the multitude of the regulatory mechanisms that are fundamental in both processes of inheritance and of development in natural systems, some researchers start exploring computationally this new(More)
Angiogenesis is a complex multistep process that comprises proliferation, migration, and anastomosis of endothelial cells, followed by stabilization of the newly formed vessel through the attachment of support cells. This process is imbalanced in a large number of disorders, including cardiovascular disease, diabetes and cancer. Evidence indicates that(More)
Evolutionary Algorithms (EA) approach differently from nature the genotype - phenotype relationship, and this view is a recurrent issue among researchers. Recently, some researchers have started exploring computationally the new comprehension of the multitude of regulatory mechanisms that are fundamental in both processes of inheritance and of development(More)
The Central Dogma of Biology states that genes made proteins that made us. This principle has been revised in order to incorporate the role played by a multitude of regulatory mechanisms that are fundamental in both the processes of inheritance and development. Evolutionary Computation algorithms are inspired by the theories of evolution and development,(More)
The Oil and Gas Exploration & Production (E&P) field deals with high-dimensional heterogeneous data, collected at different stages of the E&P activities from various sources. Over the years different soft-computing algorithms have been proposed for data-driven oil and gas applications. The most popular by far are Artificial Neural Networks, but there(More)