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Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
TLDR
Tolerant T cells display characteristic patterns of gene expression and epigenetics that are distinct from other types of T cells and are orchestrated by the transcription factor NR4A1, a potential target for tumour immunotherapy.
MicroRNAs in colorectal cancer: role in metastasis and clinical perspectives.
TLDR
This review will discuss how the aberration in the expression of miRNAs leads to the formation of CRC by effecting the regulation of their target genes, and how miRNA-based therapies to treat cancer have been emphasized lately.
Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor
TLDR
It was found that Notch signaling may simultaneously regulate Co-CSCs and chemoresistant cells and may represent a novel strategy for targeting this pathway in CRC.
MicroRNA-93 suppress colorectal cancer development via Wnt/β-catenin pathway downregulating
TLDR
The findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin, at least in part, by targeting Smad7, as an essential molecular protein for nuclear accumulation in the canonical Wnt signaling pathway.
Role of microRNA-30c Targeting ADAM19 in Colorectal Cancer
TLDR
This study provides the new insight that miR-30c inhibited colon cancer cells via targeting ADAM19, and might serve as a promising therapeutic strategy for colon cancer treatment.
Role of MicroRNA 30a Targeting Insulin Receptor Substrate 2 in Colorectal Tumorigenesis
TLDR
This study provides the first evidence that miR-30a suppressed colon cancer cell growth through inhibition of IRS2, and might serve as a promising therapeutic strategy for colon cancer treatment.
Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy
TLDR
Investigating the potential prognostic value of minichromosome maintenance (MCM) genes in patients with early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy indicates that MCM2–7 were upregulated in pancreatic cancer tumor tissues, and mRNA expression of MCM4 may serve as an independent prognostic indicator for PDAC OS prediction after pancreasicodumodectomy.
Long non-coding RNA TUG1 mediates 5-fluorouracil resistance by acting as a ceRNA of miR-197-3p in colorectal cancer
TLDR
This study suggests that TUG1 mediates 5-Fu resistance in CRC via miR-197-3p/TYMS axis.
Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma
TLDR
The study indicated that MCM2-7 genes may be potential diagnostic biomarkers in patients with HCC and among them, MCM 2 and MCM6 may serve as potential prognostic biomarkers for HCC.
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