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Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.
TLDR
CNPY2 may play a critical role in CRC development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway.
The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway
TLDR
The findings suggest that ANKRD49 plays an important role in spermatogenesis via promotion of autophagy-dependent survival and inhibition of NF-κB pathway by its inhibitors or p65 siRNA prevents the AN KRD49-dependent autophagic augmentation.
MicroRNA‐128 confers protection against cardiac microvascular endothelial cell injury in coronary heart disease via negative regulation of IRS1
TLDR
The effect of microRNA‐128 (miR‐128) on the CMEC injury in coronary heart disease (CHD) by binding to insulin receptor substrate 1 (IRS1) is clarified.
Comparative proteomic analysis of round and elongated spermatids during spermiogenesis in mice.
TLDR
Describing the differentially expressed proteins between round and elongated spermatids in mice using label-free quantitative mass spectrometry may provide valuable information for a better understanding of spermiogenesis and help improve the diagnosis and treatment of male factor infertility.
Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke-induced lung inflammation in a murine disease model of COPD
TLDR
RCC16 has therapeutic effects on COPD by downregulating pro-inflammatory factors via the NF-κB pathway and reducing the production of tumor necrosis factor, interleukin (IL)-6 and IL-8, which were induced by CS exposure.
DNA vaccination with a gene encoding Toxoplasma gondii Rhoptry Protein 17 induces partial protective immunity against lethal challenge in mice
TLDR
The data suggest that DNA vaccination with TgROP17 triggers significant humoral and cellular responses and induces effective protection in mice against acute T. gondii infection, indicating that Tg rhoptry protein 17 is a promising vaccine candidate against acute toxoplasmosis.
TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner.
TLDR
It is suggested that TWEAK may represent a cardioprotective factor that inhibits the myocyte death of myocardial IRI and protected the cardiac apoptosis by activation of cardioprotsective signaling PI3K/AKT during I/R.
Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects
TLDR
Folate deficiency activated Wnt/β-catenin pathway by upregulating a chorion-specific transcription factor Gcm1, and thus leaded into aberrant vertebrate neural development.
Screening and evaluation of human single-chain fragment variable antibody against hepatitis B virus surface antigen.
TLDR
The anti-HBsAg ScFv successfully produced by phage antibody technology may be useful for broadening the scope of application of the antibody.
Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis
TLDR
The research systematically characterized the regulatory cascades of HNF4A, HSF1, MECP2 and RAD21 in colorectal cancer metastasis and inferred the associations between the target genes by Bayesian networks and identified LMO7 and ARL8A as potential clinical biomarkers.
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