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OBJECTIVE To examine the relationship between specific thyroid abnormalities (subclinical hypothyroidism, hypothyroxinaemia or elevated thyroid peroxidase antibody titres) in women during pregnancy and the subsequent neuropsychological development of their offspring. DESIGN/PATIENTS Serum was collected from 1268 women at 16-20 weeks of gestation and(More)
Human age provides key demographic information. It is also considered as an important soft biometric trait for human identification or search. Compared to other pattern recognition problems (e.g., object classification, scene categorization), age estimation is much more challenging since the difference between facial images with age variations can be more(More)
BS69 (also called ZMYND11) contains tandemly arranged PHD, BROMO, and PWWP domains, which are chromatin recognition modalities. Here, we show that BS69 selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3) via its chromatin-binding domains. We further identify BS69 association with RNA splicing regulators, including the U5 snRNP(More)
Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD(UHRF1)), an important regulator of DNA CpG methylation, as a histone H3 unmodified arginine 2 (H3R2) recognition modality. This conclusion is based on binding studies and cocrystal(More)
BACKGROUND To compare the radiation-induced temporal lobe injury (TLI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) or two-dimensional conventional radiotherapy (2D-CRT). PATIENTS AND METHODS 1276 cases of NPC treated with IMRT or 2D-CRT were retrospectively reviewed. A diagnosis of TLI was made on(More)
AIMS microRNA-101 (miR-101) is down-regulated in several cancers. In this study, we explored the effects of dysregulated miR-101 on breast cancer cells and the underlying mechanisms. METHODS miR-101 level was quantified by real-time RT-PCR. Cell viability was analyzed by MTT assay. Apoptosis was detected by flow cytometry and TUNEL assay. Moreover, the(More)
BACKGROUND High density lipoprotein (HDL) was reported to decrease plasma glucose and promote insulin secretion in type 2 diabetes patients. This investigation was designed to determine the effects and mechanisms of HDL on glucose uptake in adipocytes and glycogen synthesis in muscle cells. METHODS AND RESULTS Actions of HDL on glucose uptake and GLUT4(More)
Dysosma (Berberidaceae), which comprises seven herbaceous perennial species, has long been used as main sources of a traditional Chinese medicine, “Guijiu.” Despite its ecological and economic importance, molecular research of Dysosma has lagged behind because of the shortcoming of molecular markers. In this study, a cDNA library of D. versipellis leaves(More)
OBJECTIVE In order to study the role of porcine CD151 in infection of porcine cells by porcine reproductive and respiratory syndrome virus (PRRSV), we established a porcine CD151 transgenic PK-15 cell line. METHODS The full-length complementary DNA (cDNA) for porcine CD151 was amplified from porcine alveolar macrophages by reverse transcription-polymerase(More)
Current simulation technologies support at most hundreds of thousands of nodes, and fall short on the emerging large-scale networking systems that usually involve millions of nodes. We meet this challenge with our distributed simulation engine that is able to run millions of instances and is tested with a production P2P protocol, using commodity PC(More)