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PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.
Histone methylation occurs on both lysine and arginine residues, and its dynamic regulation plays a critical role in chromatin biology. Here we identify the UHRF1 PHD finger (PHD(UHRF1)), anExpand
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Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex
Regulation of enhancer activity is important for controlling gene expression programs. Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histoneExpand
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Alcohol and Acetaldehyde in Public Health: From Marvel to Menace
  • Rui Guo, J. Ren
  • Medicine
  • International journal of environmental research…
  • 25 March 2010
Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and socialExpand
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Involvement of miR-133a and miR-326 in ADM resistance of HepG2 through modulating expression of ABCC1
Abstract Recent studies have shown that a class of small, functional RNAs, named microRNAs, may regulate multidrug resistance-associated protein 1 (ABCC1). Since ABCC1 is an important effluxExpand
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Comparison of emerging ground propulsion systems for electrified aircraft taxi operations
Abstract Aviation is a mode with high fuel consumption per passenger mile and has significant environmental impacts. It is important to seek ways to reduce fuel consumption by the aviation sector,Expand
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An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies
  • H. Wang, W. Li, +5 authors J. Hu
  • Biology, Medicine
  • International journal of cancer
  • 15 December 2014
RUNX1, a master regulator of hematopoiesis, is the most commonly perturbed target of chromosomal abnormalities in hematopoietic malignancies. The t(8;21) translocation is found in 30–40% of cases ofExpand
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Gene Expression Profiles in Different Stages of Mouse Spermatogenic Cells During Spermatogenesis1
Abstract During spermatogenesis, diploid stem cells differentiate, undergo meiosis and spermiogenesis, and transform into haploid spermatozoa. Various factors have been demonstrated to regulate thisExpand
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Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress.
  • M. Dong, N. Hu, +7 authors J. Ren
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 June 2013
Sepsis is characterized by systematic inflammation and contributes to cardiac dysfunction. This study was designed to examine the effect of protein kinase B (Akt) activation onExpand
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Matrine Inhibits Breast Cancer Growth Via miR-21/PTEN/Akt Pathway in MCF-7 Cells
Background: Matrine is one of the major alkaloids extracted from Sophora flavescens and has been used clinically for breast cancer with notable therapeutic efficacy in China. However, the mechanismsExpand
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Alcohol Dehydrogenase Accentuates Ethanol-Induced Myocardial Dysfunction and Mitochondrial Damage in Mice: Role of Mitochondrial Death Pathway
Objectives Binge drinking and alcohol toxicity are often associated with myocardial dysfunction possibly due to accumulation of the ethanol metabolite acetaldehyde although the underlying mechanismExpand
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