Rui Costa

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Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and Parkinson's disease, suggesting that dopamine plays a role in regulating the sleep-wake cycle. Here, we(More)
BACKGROUND Clinical trials show that asthma can be controlled in the majority of patients, but poorly controlled asthma still imposes a considerable burden. The level of asthma control achieved reflects the behaviour of both healthcare professionals and patients. A key challenge for healthcare professionals is to help patients to engage in self-management(More)
Prion (PrP) and amyloid-beta (Abeta) peptides are involved in the neuronal loss that occurs in Prion disorders (PrD) and Alzheimer's disease (AD), respectively, partially due to Ca(2+) dysregulation. Besides, the endoplasmic reticulum (ER) stress has an active role in the neurotoxic mechanisms that lead to these pathologies. Here, we analyzed whether the(More)
— Video delivery has become a major challenge for mobile networks. The increasing spread of smartphones, along with the expanding availability of LTE coverage, has contributed to an extensively growing mobile video demand, bringing large volumes of video traffic and far exceeding the capacity of mobile networks. As a result, wireless access congestion is(More)
This randomized, double-blind, double-dummy, multicenter trial compared efficacy and safety of tramadol HCL 37.5 mg/paracetamol 325 mg combination tablet with tramadol HCL 50 mg capsule in the treatment of postoperative pain following ambulatory hand surgery with iv regional anesthesia. Patients received trial medication at admission, immediately after(More)
This paper addresses aspects of design of WiMAX Wireless networks to establish a point-to-point, PTP, link with Alvarion BreezeNET B equipment, from the Health Sciences Faculty of University of Beira Interior to Hospital Sousa Martins (Guarda), and also presents a field trial with pre-WiMAX PTP equipment. The design of the link with relays had into(More)
  • Joana M. Silva, Nicole Georgi, Rui Costa, Praveen Sher, Rui L. Reis, Clemens A. Van Blitterswijk +2 others
  • 2013
Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositing the polyelectrolytes chitosan (CHT) and chondroitin sulphate (CS) on either bidimensional glass surfaces or(More)
BACKGROUND Kinesiology tape seems to improve muscle force, although little is known regarding its effect on latency time and postural sway. OBJECTIVES To examine the effects of kinesiology taping on fibularis longus latency time and postural sway in healthy subjects. METHODS Thirty participants were equally randomized into three groups, two experimental(More)