Rufaro Kashangura

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BACKGROUND The existing Bacillus Calmette–Guérin (BCG) vaccination provides partial protection against tuberculosis (TB). The modified vaccinia ankara virus-expressing antigen 85A (MVA85A) aims to boost BCG immunity. We evaluated the animal evidence supporting the testing of MVA85A in humans. METHODS Our protocol included in vivo preclinical studies of(More)
open approach, and this is exemplified by the large number of publications (many of which are listed in, and the subject of the review) where we report our findings on MVA85A, and several other vaccine candidates which have progressed to clinical trials. Despite it being explicitly highlighted in the original publication, Kashangura et al. have failed to(More)
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