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Neuroanatomical and Neurochemical Substrates of Timing

• Jennifer T. Coull, Ruey-Kuang Cheng, Warren H. Meck
• Neuropsychopharmacology
• 2011

We all have a sense of time. Yet, there are no sensory receptors specifically dedicated for perceiving time. It is an almost uniquely intangible sensation: we cannot see time in the way that we see… (More)

Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception.

• Ruey-Kuang Cheng, Yusuf Mohammed Ali, Warren H. Meck
• Neurobiology of learning and memory
• 2007

The present study examined the clock-speed modulating effects of acute cocaine administration in groups of male rats that received different amounts of baseline training on a 36-s peak-interval… (More)

Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice.

• Warren H. Meck, Ruey-Kuang Cheng, Christopher J. MacDonald, Raul R. Gainetdinov, M. Caron, Münire Özlem Çevik
• Neuropharmacology
• 2012

The dopamine transporter (DAT) is the major regulator of the spatial and temporal resolution of dopaminergic neurotransmission in the brain. Hyperdopaminergic mice with DAT gene deletions were… (More)

Differential effects of cocaine and ketamine on time estimation: implications for neurobiological models of interval timing.

• Ruey-Kuang Cheng, Christopher J. MacDonald, Warren H. Meck
• Pharmacology, biochemistry, and behavior
• 2006

The present experiment examined the effects of cocaine (0.0 and 15 mg/kg, i.p.) and ketamine (0.0, 10.0 and 15 mg/kg, i.p.) on timing behavior using a 12-s differential reinforcement of low rates… (More)

Activation and inhibition of tph2 serotonergic neurons operate in tandem to influence larval zebrafish preference for light over darkness.

• Ruey-Kuang Cheng, Seetha Krishnan, Suresh Jesuthasan
• Scientific reports
• 2016

Serotonergic neurons have been implicated in a broad range of processes, but the principles underlying their effects remain a puzzle. Here, we ask how these neurons influence the tendency of larval… (More)

Dopamine receptor antagonists reverse amphetamine-induced behavioral alteration on a differential reinforcement for low-rate (DRL) operant task in the rat.

• Ruey-Kuang Cheng, R M Liao
• The Chinese journal of physiology
• 2007

Previous studies have shown that amphetamine significantly alters operant responding on the behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral… (More)

Habit formation and the loss of control of an internal clock: inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine

• Ruey-Kuang Cheng, Oshri L. Hakak, Warren H. Meck
• Psychopharmacology
• 2007

Drugs that modulate the effective level of dopamine (DA) in cortico-striatal circuits have been shown to alter the perception of time in the seconds-to-minutes range. How this relationship changes as… (More)

Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior.

• Ruey-Kuang Cheng, Christopher J. MacDonald, Christina L. Williams, Warren H. Meck
• Learning & memory
• 2008

Choline availability in the maternal diet has a lasting effect on brain and behavior of the offspring. To further delineate the impact of early nutritional status, we examined effects of… (More)

Impairments in timing, temporal memory, and reversal learning linked to neurotoxic regimens of methamphetamine intoxication.

• Ruey-Kuang Cheng, Mikel A. Etchegaray, Warren H. Meck
• Brain research
• 2007

Methamphetamine intoxication has long-term consequences on dopaminergic function and corticostriatal-mediated behaviors in humans and other animals. In order to determine the potential impact on… (More)

Prenatal choline supplementation increases sensitivity to time by reducing non-scalar sources of variance in adult temporal processing.

• Ruey-Kuang Cheng, Warren H. Meck
• Brain research
• 2007

Choline supplementation of the maternal diet has a long-term facilitative effect on timing and temporal memory of the offspring. To further delineate the impact of early nutritional status on… (More)

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