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  • Andrew Keller, Alexey I. Nesvizhskii, Eugene Kolker, Ruedi Aebersold
  • Medicine, Computer Science, Chemistry
  • Analytical chemistry
  • 2002 (First Publication: 1 October 2002)
  • We present a statistical model to estimate the accuracy of peptide assignments to tandem mass (MS/MS) spectra made by database search applications such as SEQUEST. Employing the expectationContinue Reading
  • Steven P. Gygi, Beate Rist, Scott A. Gerber, František Tureček, Michael H. Gelb, Ruedi Aebersold
  • Medicine, Biology
  • Nature Biotechnology
  • 1999 (First Publication: 1 October 1999)
  • We describe an approach for the accurate quantification and concurrent sequence identification of the individual proteins within complex mixtures. The method is based on a class of new chemicalContinue Reading
  • Ludovic Cj Gillet, Pedro Navarro, +5 authors Ruedi Aebersold
  • Chemistry, Medicine
  • Molecular & cellular proteomics : MCP
  • 2012 (First Publication: 1 June 2012)
  • Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a biological sample. However, with theContinue Reading
  • Tong Yang, Peter J. Espenshade, +5 authors Michael Stuart Brown
  • Medicine, Biology
  • Cell
  • 2002 (First Publication: 1 August 2002)
  • Using coimmunoprecipitation and tandem mass spectrometry, we identify INSIG-1 as an ER protein that binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP) and facilitatesContinue Reading
  • Bruno Domon, Ruedi Aebersold
  • Chemistry, Medicine
  • Science
  • 2006 (First Publication: 14 April 2006)
  • Mass spectrometry is a central analytical technique for protein research and for the study of biomolecules in general. Driven by the need to identify, characterize, and quantify proteins at everContinue Reading