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Biosynthesis and Reactivity of Cysteine Persulfides in Signaling.
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is viaExpand
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Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation† †Electronic supplementary information (ESI) available. See
H2S signals via protein persulfidation. To be regulatory the modification will have to be reversible. Using a new method for persulfide detection, we discover this missing link and show thatExpand
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Does perthionitrite (SSNO(-)) account for sustained bioactivity of NO? A (bio)chemical characterization.
Hydrogen sulfide (H2S) and nitric oxide (NO) are important signaling molecules that regulate several physiological functions. Understanding the chemistry behind their interplay is important forExpand
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Working with "H2S": facts and apparent artifacts.
Hydrogen sulfide (H2S) is an important signaling molecule with physiological endpoints similar to those of nitric oxide (NO). Growing interest in its physiological roles and pharmacological potentialExpand
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Nitrosopersulfide (SSNO−) decomposes in the presence of sulfide, cyanide or glutathione to give HSNO/SNO−: consequences for the assumed role in cell signalling
The emergence of hydrogen sulfide (H2S) as a new signalling molecule able to control vasodilation, neurotransmission and immune response, prompted questions about its possible cross-talk with theExpand
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Insights into the mechanism of the reaction between hydrogen sulfide and peroxynitrite.
Hydrogen sulfide and peroxynitrite are endogenously generated molecules that participate in biologically relevant pathways. A revision of the kinetic features of the reaction between peroxynitriteExpand
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Synthesis and Pharmacological Evaluation of Novel Adenine-Hydrogen Sulfide Slow Release Hybrids Designed as Multitarget Cardioprotective Agents.
This work deals with the design, synthesis, and evaluation of the cardioprotective properties of a number of novel hybrid compounds combining the adenine nucleus with a suitable H2S slow-releasingExpand
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Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA
Hydrogen sulfide (H2S) is produced endogenously in vivo and has multiple effects on signaling pathways and cell function. Mitochondria can be both an H2S source and sink, and many of the biologicalExpand
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