Rudolf Stöger

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The mouse insulin-like growth factor type 2 receptor (Igf2r) is imprinted and expressed exclusively from the maternally inherited chromosome. To investigate whether methylation could function as the imprinting signal, we have cloned 130 kb from the Igf2r locus and searched for sequences methylated in a parental-specific manner. Two regions have been(More)
T-associated maternal effect (Tme) is the only known maternal-effect mutation in the mouse. The defect is nuclear-encoded and embryos that inherit a deletion of the Tme locus from their mother die at day 15 of gestation. There are many genomically imprinted regions known in the mouse genome but so far no imprinted genes have been cloned. The Tme locus is(More)
The human IGF2R gene has been reported to be either biallelically or very rarely monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We describe here an analysis of the 5' portion of the human IGF2R gene and show that it contains a maternally methylated CpG island in the second intron. A similar maternally methylated(More)
Die Chronisch Venöse Insuffizienz (CVI), unter deren Begriff sowohl primäre/idiopathische Abnormitäten des Venensystems sowie sekundäre Folgen nach Tiefer Venenthrombose zusammengefasst werden, stellt in westlichen Ländern ein bedeutendes Gesundheitsproblem dar. In der aktuellen Studie wurde die Hypothese untersucht, ob die Entwicklung einer CVI durch(More)
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