Rudolf Hergt

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Loss processes in magnetic nanoparticles are discussed with respect to optimization of the specific loss power (SLP) for application in tumour hyperthermia. Several types of magnetic iron oxide nanoparticles representative for different preparation methods (wet chemical precipitation, grinding, bacterial synthesis, magnetic size fractionation) are the(More)
Magnetic nanoparticles are promising tools for the minimal invasive elimination of small tumours in the breast using magnetically-induced heating. The approach complies with the increasing demand for breast conserving therapies and has the advantage of offering a selective and refined tuning of the degree of energy deposition allowing an adequate(More)
PURPOSE To assess relevant parameters for the minimally invasive elimination of breast tumors by using a selective application of magnetite and exposure of the breast to an alternating magnetic field. MATERIALS AND METHODS The specific absorption rate (SAR) of different magnetite samples was determined calorimetrically. Temperature elevations based on(More)
In this review article we present basic principles of magnetically induced heat generation of magnetic nanoparticles for application in magnetic particle hyperthermia. After explanation of heating mechanisms, the role of particle-particle as well as particle-tissue interactions is discussed with respect to achievable heating power of the particles inside(More)
RATIONALE AND OBJECTIVE Feasibility of a new interventional procedure for the treatment of breast cancer called "magnetic thermal ablation" was examined under in vivo animal conditions. The method consists in the intratumoral application of iron oxide particles and the exposure of the breast to an alternating magnetic field, whereby the tumor is eliminated(More)
RATIONALE AND OBJECTIVES To study the effects of magnetic thermoablation in muscle tissue from cow to assess interrelations that might be relevant for a minimally invasive therapy system in the long term. METHODS Magnetite particles (50-180 mg) were placed in muscle tissue. Temperature elevations as a function of time and distance from the center of the(More)
RATIONALE AND OBJECTIVES The biologic effects of magnetically induced heating effects using iron oxide, magnetite, were examined in vitro in liver tissue samples as a first step toward potential applications in cancer therapy. METHODS For the determination of the temperature profile around an iron oxide sample, a cylinder containing 170 mg of magnetite(More)
The aim of this study was to characterize the behaviour of cisplatin adsorbed magnetic nanoparticles (cis-MNPs) for minimal invasive cancer treatments in preliminary in vitro investigations. Cisplatin was adsorbed to magnetic nanoparticles (MNPs) by simple incubation. For stability determinations, cis-MNPs were incubated in dH(2)O, phosphate-buffered saline(More)
For understanding hysteresis losses of magnetic nanoparticles to be used for magnetic particle hyperthermia the effect of size distribution on the dependence of hysteresis losses on magnetic field amplitude is studied on the basis of a phenomenological model in the size range from superparamagnetism to magnetic multi-domains-roughly 10 up to 100 nm. Relying(More)