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Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiotherapy is important in the treatment of(More)
Distant metastases are the major cause of morbidity and mortality in women with breast cancer. The ability to predict the metastatic proclivity is essential in choosing the optimal treatment. Tumor size and grade, which are frequently used markers in node-negative breast cancer patients, are inadequate markers for prognosis and individualized treatment(More)
Vispol (Visualization for the police) is an interactive graph-based visualization that supports the work of the police of Hessen, Germany. A Vispol graph visualizes involved persons and their relations in crisis incidents like hostage takings or bank holdups. It presents a tabletop-based multi-touch and tangible user interface for the structured creation(More)
The characteristics of cervicography and the Papanicolaou smear test have been compared for the detection of cervix lesions classified as CIN I or more. A total of 4,015 women were entered into the study. The sensitivity of cervicography is significantly higher (McNemar test, P < 0.0001), but its specificity remains significantly lower (McNemar test, P <(More)
Polizeiliche Entscheidungsfindung ist kein beliebiger Prozess. Notwendige Überprüfbarkeit im Rahmen rechtsstaatlichen Handelns ist kein " wäre schön wenn " , sondern in unserem demokratischen Rechtsstaat ein unabdingbares " muss ". Welches Hilfsmittel die hessische Polizei nutzt, um dieser gesetzlichen Aufgabe zu entsprechen, auf welche Grundlagen hierbei(More)
Strategies to sensitize human tumors that are resistant to apoptosis have been clinically unsuccessful. We demonstrate that a structurally modified chimeric Pseudomonas exotoxin, PEdelta53L/TGF-alpha/KDEL, with binding specificity for the epidermal growth factor receptor, markedly enhances sensitivity of human xenografts to radiation killing. Exposure to(More)
Clinical, radiological, surgical, and histological features are reported for a patient with a temporal lobe oligodendroglioma that had developed in infancy and was diagnosed and partially resected at age 10. The patient is presently 24 years old and still well. To the best of our knowledge this is the first report of an oligodendroglioma with probable onset(More)
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