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FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the(More)
Dipeptidylpeptidase 4 (DPP4/CD26) enzymatically cleaves select penultimate amino acids of proteins, including colony-stimulating factors (CSFs), and has been implicated in cellular regulation. To better understand the role of DPP4 regulation of hematopoiesis, we analyzed the activity of DPP4 on the surface of immature blood cells and then comparatively(More)
Four anti-glucocorticoids, 11-deoxycortisol, deoxycorticosterone, 17 alpha-methyltestosterone and progesterone were demonstrated to antagonize the stimulation of mouse mammary tumor virus (MMTV) production by the glucocorticoid hormone dexamethasone in the cell line Mm5mt. These same anti-glucocorticoids were also able to suppress the enhancement of MMTV(More)
The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promote microglia-mediated clearance. In this study, we investigated whether antibody effector function is required for(More)
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