Rubens Marschalek

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In this paper the authors present the first evidence that meningiomas respond to treatment with hydroxyurea. Hydroxyurea was administered as an adjunct chemotherapeutic treatment in patients with recurrent and unresectable meningiomas. Hydroxyurea was used because experimental data demonstrated that it inhibits growth of cultured human meningioma cells and(More)
Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with(More)
Though meningiomas are benign intracranial tumors, a minor group invades the skull base and the connective tissue of the sinus cavernous inducing neurological deficits. These patients can not be cured by surgical treatment. Therefore, the development of an adjuvant medical therapy has been the goal during the last decade. We report here on different medical(More)
OBJECT It has been demonstrated that growth of cerebral meningiomas found in humans is controlled by a variety of factors, including growth factors, aminergic agents, neuropeptides, and steroids. To further our knowledge of this process, the authors investigated the presence and function of the cytokines leukemia inhibitory factor (LIF), interleukin-6(More)
The increasing application of heavy ions in radiotherapy and the growing interest in protracted space travels are a strong motivation to expand the fundamental research in radiation biology. With respect to long term effects in different cell systems, in the majority of studies the occurrence of chromosomal aberrations is assessed, but only in lymphocytes.(More)
The increasing application of heavy ions in radiotherapy is a strong motivation to expand the fundamental research in radiation biology, especially with respect to long term effects in different cell systems. The classical cytogenetic assay to estimate the radiation effect relies only on the measurement of chromosome aberrations in lymphocytes, but a large(More)
In multicellular organisms stem cells are involved in tissue regeneration, which is regulated by apoptosis (programmed cell death). An early event of apoptosis is the externalisation of membrane phospholipids to the extracellular environment, on which Annexin-V is able to bind with a high affinity. The later stages of apoptosis are characterized by the loss(More)
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