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Early development of mammalian embryos occurs in an environment of relative hypoxia. Nevertheless, human embryonic stem cells (hESC), which are derived from the inner cell mass of blastocyst, are routinely cultured under the same atmospheric conditions (21% O(2)) as somatic cells. We hypothesized that O(2) levels modulate gene expression and differentiation(More)
Understanding the transcriptional cues that direct differentiation of human embryonic stem cells (hESCs) and human-induced pluripotent stem cells to defined and functional cell types is essential for future clinical applications. In this study, we have compared transcriptional profiles of haematopoietic progenitors derived from hESCs at various(More)
BACKGROUND Cell culture media conditioned by human foreskin fibroblasts (HFFs) provide a complex supplement of protein and metabolic factors that support in vitro proliferation of human embryonic stem cells (hESCs). However, the conditioning process is variable with different media batches often exhibiting differing capacities to maintain hESCs in culture.(More)
  • bullet Cns, Sponsorship Chair, Robert J Butera Georgia, Aurel A Lazar, Ruben Moreno, Bote Universitat De Barcelona +2 others
  • 2014
Fundraising OCNS, Inc is a US non-profit, 501(c)(3) serving organization supporting the Computational Neuroscience community internationally. We seek sponsorship from corporate and philantropic organizations for support of student travel and registration to the annual meeting, student awards and hosting of topical workshops. We can also host booth(More)
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