Ru-lai Yang

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OBJECTIVE To investigate the mechanism for the apoptosis of hippocampus neuron induced by hypothyroidism in perinatal rats. METHODS Hypothyroidism was induced by administration of propylthiouracil (PTU, 50 mg/d) solution to the dams from gestational day 15 by gavage. Pups from both hypothyroid and control groups were harvested at 1, 5, 10 and 15d,(More)
BACKGROUND This study was undertaken to explore the clinical outcome and prognosis of subclinical hypothyroidism detected by newborn screening. METHODS Newborn screening was conducted at 1156 health care institutions in Zhejiang Province from October 1999 to September 2006. Included were (1) infants who had thyroid-stimulating hormone (TSH) ≥ 20 mU/L, and(More)
OBJECTIVE To investigate the correlation of congenital hypothyroidism (CH) with birth weight and gestational age in newborn infants. METHODS The screening of CH was conducted in all the live births in 2005 of Zhejiang Province, the blood samples were collected from heel stick. The thyroid stimulating hormone (TSH) was measured by time-resolved(More)
OBJECTIVE To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH). METHODS Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4). Follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland(More)
OBJECTIVE To study the best observation time for drug administration and withdrawal in the treatment of children with transient congenital hypothyroidism,seeking an objective basis for the safe drug withdrawal. METHODS Levothyroxine was prescribed for 1 144 children diagnosed with congenital hypothyroidism (CH) and according to the results levothyroxine(More)
OBJECTIVE To study the under-five mortality rate and the causes of death in Zhejiang Province between 2000 and 2009 in order to provide a basis for reducing the mortality rate in the region. METHODS By stratified random cluster sampling, all the children under 5 years old from 30 sampling areas of Zhejiang Province between 2000 and 2009 were enrolled. The(More)
OBJECTIVE To investigate the influence of lead exposure on the immune function of lymphocytes and erythrocytes in preschool children. MATERIALS AND METHODS A group of 217 children three to six years of age from a rural area were given a thorough physical examination and the concentration of lead in blood samples taken from each subject was determined. The(More)
BACKGROUND It has been 11 years since newborn screening started in Zhejiang in 1999. The aim of this study was to analyze and summarize the status of newborn screening in Zhejiang from 1999 to 2009. METHODS Blood samples were collected from the heels of newborns 72 hours after birth. We have conducted laboratory tests that the congenital hypothyroidism(More)
OBJECTIVE To analyze the data of screening for congenital hypothyroidism (CH) newborns in Zhejiang Province during 1999-2004. METHODS The dried blood samples were collected on filter paper. The levels of thyroid-stimulating hormone (TSH) were measured by time-resolved fluoroimmunoassay, and the serum levels of TSH, triiodothyronine (T(3)) and thyroxine(More)