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In mammals, genome-wide chromatin maps and immunofluorescence studies show that broad domains of repressive histone modifications are present on pericentromeric and telomeric repeats and on the inactive X chromosome. However, only a few autosomal loci such as silent Hox gene clusters have been shown to lie in broad domains of repressive histone(More)
Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head(More)
A fully integrated LNA suitable for ultra-low-voltage and ultra-low-power applications is designed in 0.13 mum CMOS technology. A two-stage common-source configuration and forward-body-bias MOSFET are employed to reduce the supply voltage. The proposed LNA exhibits 14.3dB power gain and 2.93dB noise figure at 5GHz while consuming only 0.64mW DC power at the(More)
Self-aligned double patterning (SADP) has become a promising technique to push pattern resolution limit to sub-22nm technology node. Although SADP provides good overlay controllability, it encounters many challenges in physical design stages to obtain conflict-free layout decomposition. In this paper, we study the impact on placement by different standard(More)
BACKGROUND AND PURPOSE A new simple visual rating scale can be used in magnetic resonance imaging (MRI) to grade the severity of white matter changes (WMC). The authors sought to study the interobserver variability and the validity of this visual rating scale against a computer-aided quantitative method in measuring WMC. METHODS The authors examined 220(More)
It is predicted that CMOS technology will probably enter into 22 nm node around 2012. Scaling of CMOS logic technology from 32 to 22 nm node meets more critical issues and needs some significant changes of the technology, as well as integration of the advanced processes. This paper will review the key processing technologies which can be potentially(More)
BACKGROUND AND PURPOSE Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent of WMC affect the type and degree of cognitive impairment in patients with lacunar infarct is not clear. The study was undertaken to determine if WMC influences cognition in patients with lacunar(More)