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BF3·Et2O catalyzed diastereoselective nucleophilic reactions of 3-silyloxypiperidine N,O-acetal with silyl enol ether and application to the asymmetric synthesis of (+)-febrifugine
Abstract The asymmetric BF 3 ·Et 2 O catalyzed nucleophilic reactions of 3-silyloxypiperidine N , O -acetal 10 with silyl enol ethers derived from ketones are described. (+)-Febrifugine 1 , anExpand
Concise asymmetric synthesis of (-)-deoxoprosophylline
Abstract An efficient asymmetric synthesis of the 2-hydroxymethyl 3,6-disubstituted piperidine alkaloid, (−)-deoxoprosophylline, is described. The key step of this route is the SmI 2 -mediatedExpand
A flexible approach to construct three contiguous chiral centers of sphingolipids, and asymmetric synthesis of d-ribo-phytosphingosine and its derivatives
Abstract An efficient approach to build the three contiguous stereogenic centers of sphingosine unit starting from cheap glutamic acid is described. The key step of this approach is the SmI 2Expand
Asymmetric Total Synthesis of (-)-deoxoprosophylline
The SmI2 induced cross-coupling of chiral N-tert-butanesulfinyl imine 10 with aldehyde 11 to form hydroxymethyl-β-amino alcohol 9(yield, 77%) with high diastereoselectivity (>99%, de) is described inExpand
Role of Railway Transportation in the Spread of the Coronavirus: Evidence From Wuhan-Beijing Railway Corridor
The last few months have marked a notable surge in COVID-19. The disease has infected 10 million people around the world and has gained attention in the field of research. Allegedly originating inExpand