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Preventive agents for neurodegenerative diseases from resin of Dracaena cochinchinensis attenuate LPS-induced microglia over-activation

Chalcone 9, homoisoflavane 5 and flavone 12–14 are considered to be responsible for the anti-neuroinflammatory effects of Chinese Dragon’s blood, which could inhibit neuroinflammation by reducing the expressions of iNOS, IL-6 and TNF-α in over-activated microglial.
Springer (opens in a new tab)

Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways

Okanin attenuates LPS-induced activation of microglia and may have potential as a nutritional preventive strategy for neurodegenerative disorders.
Springer (opens in a new tab)

Nomogram prediction of severe risk in patients with COVID-19 pneumonia

Using the model, clinicians can intervene early, improve therapeutic effects and reduce the severity of COVID-19, thus ensuring more targeted and efficient use of medical resources.
Cambridge Press (opens in a new tab)

Isoamericanin A improves lipopolysaccharide‐induced memory impairment in mice through suppression of the nicotinamide adenine dinucleotide phosphateoxidase‐dependent nuclear factor kappa B signaling…

A novel pharmacological activity of ISOA is revealed: ameliorating memory impairment in AD via inhibiting neuroinflammation through inhibition of superoxide and intracellular reactive oxygen species accumulation.
Wiley (opens in a new tab)

Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro

The primary mechanism of the bioactivities and stereoselectivity was explored by means of bioassay and molecular docking and the unique 9-O-9′−7, 9′-cyclo-8, 1′-neolignan skeleton with a seven-membered ring, was identified.
Springer (opens in a new tab)

Tamarix hohenackeri Bunge exerts anti-inflammatory effects on lipopolysaccharide-activated microglia in vitro.

PubMed (opens in a new tab)
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