Rozanne Richman

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We studied the effect of thyroid hormone administration on responsivity of murine thyroid to exogenous thyrotropin (TSH) in order to explore the possibility that the thyroid gland might be directly inhibited by its own hormones. In the rat both L-thyroxine (T4) and 3,5,3'-L-triiodothyronine (T3) pretreatment inhibited TSH-induced thyroidal ornithine(More)
Previous studies have used conventional electron microscopy and freeze fracture to identify the morphological equivalents of the blood–aqueous barrier in the mammalian eye. These equivalents are the tight junctions that form a part of the apicolateral junctional complex between adjacent non-pigmented ciliary epithelial cells and the tight junctions present(More)
To evaluate the growth promoting effects of GH and IGF-I in normal animals, we infused vehicle (0.1 M acetic acid), twine GH (3.3 mg/kg/day), or recomhinanl human IGF-I (1,2 mg/kg/day) (n = 5 per group) for 2 weeks via indwelling osmotic minipumps to Fischer 344 male rats, aged 2 (immature) and 8 mo (mature). Regardless of the treatment, all immature rats(More)
We studied the effects of TSH on rat thyroid ornithine decarboxylase (ODC) activity. After 1 day of goitrogen treatment, there was an abrupt fall in serum triiodothyronine (T3) a rise in circulating TSH, and a dramatic increase in thyroid ODC activity. Despite the continued rise in TSH and progressive increase in thyroid gland size with further treatment,(More)
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