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INTRODUCTION Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood(More)
Microglial cells are the subset of macrophages in the central nervous system (CNS). Changes in the CNS such as injury or developmental events cause morphological and physiological changes in microglial cells. In this study organotypic brain slice cultures under serum free condition were used to investigate the morphology and lectin histochemistry of(More)
The exact developmental origin of microglia is still under debate. In the present study we investigated which heamatopoietic tissues and which features of the organotypic brain slice culture promoted microglia ramification. The potential of cells derived from embryonic yolk sac, embryonic aorta-gonad-mesonephros and adult blood monocytes was examined. These(More)
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