Roya Dadmarz

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PURPOSE To correlate in vitro characteristics of tumor-infiltrating lymphocytes (TIL) with clinical response to TIL immunotherapy in patients with metastatic melanoma. PATIENTS AND METHODS Forty-one melanoma patients undergoing 43 separate treatment courses with TIL and interleukin-2 (IL-2) from December 1990 through November 1992 were studied(More)
Tumor-infiltrating lymphocytes (TIL) were derived from primary breast tumors, metastatic lymph nodes and malignant pleural effusions from 34 patients with breast cancer. TIL were cultured for approximately 30 days and studied for phenotype, cytotoxicity, and the ability to secrete cytokines in response to autologous tumor stimulation. Tumor specimens were(More)
The relationship between alpha-interferon receptor (alpha IFNR) numbers, B-cell-antigen expression and clinical stage was determined in 35 cases of typical chronic lymphocytic leukaemia (CLL). alpha IFNR numbers were shown to be low in patients with advanced disease and high in those with a more favourable prognosis. The B-cell activation antigen CD 23 was(More)
PURPOSE To search for tumor-specific in vitro reactivity by lymphocytes derived from patients with ovarian carcinoma. METHODS Tumor-infiltrating lymphocytes (TIL) were derived from primary or metastatic solid tumors and tumor-associated lymphocytes (TAL) were derived from ascites from 13 patients with ovarian cancer. TIL or TAL were cultured for(More)
To investigate the possible direct effects of alpha-interferon (IFN-alpha) in hairy cell leukemia, IFN-alpha receptor expression by hairy cells (11 cases) was measured by a radiolabeling technique and compared with that of MOLT-4, chronic lymphocytic leukemia (15 cases), and various other leukemic and normal cell types. Purified peripheral blood and splenic(More)
Both the CD56bright and CD56dim NK cell subpopulation mediate non-major histocompatibility complex-restricted cytolysis of NK-sensitive tumor cell lines, and IL-2-dependent augmentation of cytolysis and proliferation of CD56bright and CD56dim NK cells was recently reported. We investigated the effects of IL-7 and IL-6 on the killing mediated by these cells(More)
Chronic lymphocytic leukemia of B-cell origin (B-CLL) is a disease with a variable clinical course, despite the fact that the neoplastic cells in this disorder are homogeneous with respect to morphology, immunophenotype, and cell cycle stage. To further investigate the heterogeneity observed in the clinical behavior of B-CLL, we determined the phenotype and(More)
To investigate the possible direct effects of interferon-alpha (IFN-alpha) in hairy-cell leukaemia, IFN-alpha receptor expression by hairy cells (HCs) (11 cases) was measured by a radiolabelling technique and compared with that of MOLT-4, chronic lymphocytic leukaemia (CLL; 14 cases) and various other leukaemic and normal cell types. Purified peripheral(More)
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