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The percentage of cells capable of forming colonies of at least a given size has been found to provide a reliable estimate of the remaining doubling potential of several human diploid fibroblast cell lines and for chick embryo fibroblasts. In five independently derived cell lines of human diploid fibroblasts we have found the same linear relationship(More)
At several points during the growth of a clone of human embryonic lung fibroblasts in vitro, 100 to 200 cells were removed at random and the proliferative potential of each cell was determined. At each sample point, a wide variation in remaining population doubling ability was observed among the individual cells and the distributions of doubling potentials(More)
A series of mitotic pairs of cells were isolated and the proliferative potential of each cell determined. Although the proliferative potentials of the two cells of a single pair were similar for most pairs examined, in a significant proportion large differences were observed. These results suggest a strong stochastic component in the somatic inheritance of(More)
High energy nuclear physics experiments at the Thomas Jefferson National Accelerator Facility (" Jefferson Lab ") will have a data collection rate of 10 MB/second, generating 1 Terabyte (TB) of raw data per day of accelerator running, and a similar amount after processing. The requirement for on-line disk storage for raw and reduced data sets will exceed 1(More)
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