Roy Allenspach

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In vascular tissue, T-cadherin (T-cad) is up-regulated in vivo under disease conditions associated with oxidative stress and concomitant cell migration, proliferation and apoptosis/survival. Using cultures of human umbilical vein endothelial cells (HUVEC), we examined whether there is a functional relationship between oxidative stress, T-cad expression, and(More)
Most therapeutic monoclonal antibodies (mAbs) licensed for human use or in clinical development are indicated for treatment of patients with cancer and inflammatory/autoimmune disease and as such, are designed to directly interact with the immune system. A major hurdle for the development and early clinical investigation of many of these immunomodulatory(More)
OBJECTIVE In vascular tissue, T-cadherin (T-cad) levels correlate with the progression of atherosclerosis, restenosis and tumour neovascularization. This study investigates whether T-cad influences proliferation of vascular cells. METHODS AND RESULTS Cultures of human umbilical vein endothelial cells (HUVEC) and rat and human aortic smooth muscle cells(More)
The underlying mechanisms for domain wall propagation induced by spin-polarized currents were studied. The critical parameters for current-induced wall motion such as the threshold current density at which the motion sets in, the wall velocity and their temperature dependence, were obtained experimentally. Permalloy rings with nonmagnetic contacts were(More)
Andesitic pumice erupted in 1985 from Nevado del Ruiz volcano (Colombia) has been magnetized in opposite direction t o the present geomagnetic field. This self-reversal is probably due t o an exchange mechanism between two phases of the haematite-ilmenite series, which is similar to the magnetic coupling observed in synthetically grown(More)
Spin-polarized scanning electron microscopy (spin-SEM, or SEMPA) is used to image the magnetic domain walls in nanoscale elements with a lateral resolution of 20 nm. Here it is illustrated how geometry and external excitation by spin currents influence and modify the domain wall structure.
OBJECTIVE T-cadherin (T-cad) is an atypical GPI-anchored member of the cadherin superfamily. In vascular tissue, T-cad expression is increased during atherosclerosis, restenosis, and tumor neovascularization. In vitro, overexpression and/or homophilic ligation of T-cad on endothelial cells (ECs) facilitates migration, proliferation, and survival. This study(More)
Permalloy ring structures with nonmagnetic contacts have been fabricated for transport measurements. The position of a domain wall is determined by low-temperature measurements of the resistance between different pairs of contacts. By monitoring the resistance, the threshold current density at which the current moves the domain wall is determined. Injecting(More)
In this paper, current-induced domain wall displacement experiments that are combined with high resolution imaging of the domain walls are reported. A spin-polarized scanning electron microscope is used to determine topography and magnetization distribution of Fe/sub 20/Ni/sub 80/ sub-micron wires with a zigzag geometry. Injection of a single 10 /spl mu/s(More)