Roxanne Alter

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A 58-year old male with follicular small cleaved B cell lymphoma developed pure red cell aplasia (PRCA) during chemotherapy. To understand the etiology of the PRCA, we studied the effects of patient sera on the progenitor cell colony formation of normal human bone marrow cells in vitro. We demonstrated a marked inhibition of normal bone marrow progenitor(More)
OBJECTIVE Define optimum vascular catheter connector valve disinfection practices under laboratory and clinical conditions. DESIGN Prospective observational clinical survey and laboratory assessment of disinfection procedures. SETTING All adult inpatients at an academic healthcare center. METHODS In the clinical setting, contamination of needleless(More)
The Nebraska Medical Center (TNMC) was conducting an Institutional Review Board 8 approved research study utilizing the BioFire FilmArray Gastrointestinal Panel (BioFire 9 Diagnostics, Salt Lake City, UT) when an outbreak of cyclosporiasis occurred in Iowa and 10 Nebraska (1). The FilmArray GI Panel is a culture-independent molecular test that 11(More)
BACKGROUND Etiologic agents of childhood bacteremia remain poorly defined in Nigeria. The absence of such data promotes indiscriminate use of antibiotics and delays implementation of appropriate preventive strategies. METHODS We established diagnostic laboratories for bacteremia surveillance at regional sites in central and northwest Nigeria. Acutely ill(More)
Hospital use of chlorhexidine (CHX) containing antiseptics to decrease nosocomial infections may promote CHX resistance among pathogenic organisms. Nosocomial bloodstream-infecting Staphylococcus aureus isolates from before and after adoption of hospital-wide CHX bathing were tested for CHX susceptibility, and no decreased susceptibility or(More)
BACKGROUND The burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have identified typhoid associated with Salmonella enterica serovar Typhi (S. Typhi) as an important cause of bacteremia in children. METHODS(More)
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