Roxanna M. Webber

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Although it has long been posited that sensory adaptation serves to enhance information flow in sensory pathways, the neural basis remains elusive. Simultaneous single-unit recordings in the thalamus and cortex in anesthetized rats showed that adaptation differentially influenced thalamus and cortex in a manner that fundamentally changed the nature of(More)
Cells in the rodent barrel cortex respond to vibrissa deflection with a brief excitatory component and a longer suppressive component. The response to a given deflection is thus scaled because of suppression induced by a preceding deflection, causing the neuronal response to be linked to the temporal properties of the peripheral stimulus. A(More)
Adaptation is a ubiquitous property of all sensory pathways of the brain and thus likely critical in the encoding of behaviorally relevant sensory information. Despite evidence identifying specific biophysical mechanisms contributing to sensory adaptation, its functional role in sensory encoding is not well understood, particularly in the natural(More)
Nowhere is the sparse nature of neuronal coding more evident than in the sensory cortex, where neuronal response becomes increasingly tuned to specific features of the sensory environment. For such situations, where rate modulation schemes do not accurately describe the neuronal response to sensory stimuli, statistical descriptions based on point process(More)
Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled out based on lack of an inner ear phenotype in knockout animals or pore properties not similar to the hair-cell channel. Such studies(More)
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