Roxana M. Ghiulai

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Electron transfer dissociation (ETD) has been developed recently as an efficient ion fragmentation technique in mass spectrometry (MS), being presently considered a step forward in proteomics with real perspectives for improvement, upgrade and application. Available also on affordable ion trap mass spectrometers, ETD induces specific N–Cα bond cleavages of(More)
Cutaneous melanoma is a metastatic disease characterized by high resistance to treatment, the incidence of which has alarmingly increased worldwide over the past years. A thorough characterization of tumor onset, progression and metastasis is compulsory to overcome the gaps existent in melanoma biology. The present study suggests a well‑established protocol(More)
In this study we report on the first mass spectrometric (MS) investigation of gangliosides and preliminary assessment of the expression and structure in normal fetal neocortex in early developmental stages: 14th (Neo14) and 16th (Neo16) gestational weeks. Ganglioside analysis was carried out using a hybrid quadrupole time-of-flight (QTOF) MS with direct(More)
The progress of ion mobility spectrometry (IMS), together with its association to mass spectrometry (MS), opened new directions for the identification of various metabolites in complex biological matrices. However, glycolipidomics of the human brain by IMS MS represents an area untouched up to now, because of the difficulties encountered in brain sampling,(More)
COSMIN CITU1#, CORINA DANCIU2#, IULIA PINZARU2, ROXANA GHIULAI2, LAVINIA VLAIA2, VICENTIU VLAIA2, FLORIN BORCAN2*, CATALIN DUMITRU1, IOANA ZINUCA PAVEL2, IOAN SAS1, ELENA BERNAD1 1 “Victor Babes” University of Medicine and Pharmacy Timisoara, Faculty of Medicine, 2nd Eftimie Murgu Sq., 300041, Timisoara, Romania 2 “Victor Babes” University of Medicine and(More)
The extensive biochemical research of multiple types of cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need for the discovery of new means with which to block these signaling cascades. The phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT) pathway, which plays an important(More)
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