Roxana A. Stefanescu

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Conventionally, sensory systems are viewed as separate entities, each with its own physiological process serving a different purpose. However, many functions require integrative inputs from multiple sensory systems and sensory intersection and convergence occur throughout the central nervous system. The neural processes for hearing perception undergo(More)
Tinnitus, the phantom perception of sound, is physiologically characterized by an increase in spontaneous neural activity in the central auditory system. However, as tinnitus is often associated with hearing impairment, it is unclear how a decrease of afferent drive can result in central hyperactivity. In this review, we first assess methods for tinnitus(More)
Neural networks consisting of globally coupled excitatory and inhibitory nonidentical neurons may exhibit a complex dynamic behavior including synchronization, multiclustered solutions in phase space, and oscillator death. We investigate the conditions under which these behaviors occur in a multidimensional parametric space defined by the connectivity(More)
The development of two forebrain fiber tracts, the anterior commissure (CA) and corpus callosum (CC), was examined in BALB/cCF laboratory mice in relation to the maternal dietary protein concentration during gestation. The diets contained either 8 or 27% casein. The BALB/c strain was used because it is prone to having a corpus callosum which is either(More)
Neuronal oscillations and cross-frequency interactions in the rat hippocampus relate in important ways to memory processes and serve as a model for studying oscillatory activity in cognition more broadly. We report here that hippocampal synchrony (CA3-CA1 coherence) increased markedly in the low gamma range as rats were exploring novel objects, particularly(More)
Large scale brain networks are understood nowadays to underlie the emergence of cognitive functions, though the detailed mechanisms are hitherto unknown. The challenges in the study of large scale brain networks are amongst others their high dimensionality requiring significant computational efforts, the complex connectivity across brain areas and the(More)
Interictal spikes (IISs) are spontaneous high amplitude, short time duration <400 ms events often observed in electroencephalographs (EEG) of epileptic patients. In vitro analysis of resected mesial temporal lobe tissue from patients with refractory temporal lobe epilepsy has revealed the presence of IIS in the CA1 subfield. In this paper, we develop a(More)
In the human brain, large-scale neural networks are considered to instantiate the integrative mechanisms underlying higher cognitive, motor, and sensory functions. Computational models of such large-scale networks typically lump thousands of neurons into a functional unit, which serves as the "atom" for the network integration. These atoms display a low(More)
PURPOSE Approximately 30% of epilepsy patients suffer from medically refractory epilepsy, in which seizures can not controlled by the use of anti-epileptic drugs (AEDs). Understanding the mechanisms underlying these forms of drug-resistant epileptic seizures and the development of alternative effective treatment strategies are fundamental challenges for(More)
Tinnitus has been associated with enhanced central gain manifested by increased spontaneous activity and sound-evoked firing rates of principal neurons at various stations of the auditory pathway. Yet, the mechanisms leading to these modifications are not well understood. In a recent in vivo study, we demonstrated that stimulus-timing-dependent bimodal(More)