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The Pax6 transcription factor is expressed in cerebellar granule cells and when mutated, as in the Sey/Sey mouse, produces granule cells with disturbed survival and migration and with defects in neurite extension. The impact of Pax6 on other genes in the context of cerebellar development has not been identified. In this study, we performed transcriptome(More)
1 Problem statement. We address the computational problems of discretizing continuous random variables and identifying a logical network model to account for temporal dependencies among genes and environmental stimuli from high-throughput transcriptome data. These new algorithms were applied to real biological data from an analysis of the molecular response(More)
The problem of computing logical network models to account for temporal dependencies among interacting genes and environmental stimuli from high-throughput transcriptomic data is addressed. A logical network reconstruction algorithm was developed that uses the statistical significance as a criterion for network selection to avoid false interactions arising(More)
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