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BACKGROUND Nonhuman primate models are critical for understanding mechanisms underlying human psychopathology. We established a nonhuman primate model of anxious temperament (AT) for studying the early-life risk to develop anxiety and depression. Studies have identified the central nucleus of the amygdala (Ce) as an essential component of AT's neural(More)
The lateral division of the bed nucleus of the stria terminalis (BSTL) and central nucleus of the amygdala (Ce) form the two poles of the ‘central extended amygdala’, a theorized subcortical macrostructure important in threat-related processing. Our previous work in nonhuman primates, and humans, demonstrating strong resting fMRI connectivity between the Ce(More)
Overexpressing corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit corticotropin-releasing hormone (CRH) in the primate amygdala increases anxious temperament and alters its neural circuit, Biological Psychiatry, This is a PDF file of an unedited manuscript that has been accepted for(More)
First, I would like to express my thanks and gratitude to my thesis adviser Dr. John Salamone not only for providing me with the opportunity to conduct my own experiment, but also for his guidance, support, compassion, encouragement and enthusiasm both throughout this process and at my time at the University of Connecticut. Secondly, I would like to thank(More)
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