Learn More
BACKGROUND Whole body vibration may improve muscle and bone strength, power and balance although contradictory findings have been reported. Prolonged exposure may result in adverse effects. We investigated the effects of high (5.5 mm) and low (2.5mm) amplitude whole body vibration at various frequencies (5-30 Hz) on muscle activity and acceleration(More)
Insulin can affect metabolic functions such as glucose production and fat mobilization through action in the ventromedial nucleus of the hypothalamus (VMH), and the VMH has been implicated in the regulation of heat generation in brown adipose tissue (BAT) in the rat. To study the role of insulin in modulating VMH mechanisms concerned with BAT thermogenic(More)
Whole body vibration (WBV) has been suggested to elicit reflex muscle contractions but this has never been verified. We recorded from 32 single motor units (MU) in the vastus lateralis of 7 healthy subjects (34 ± 15.4 yr) during five 1-min bouts of WBV (30 Hz, 3 mm peak to peak), and the vibration waveform was also recorded. Recruitment thresholds were(More)
Selective stimulation of ventromedial hypothalamic nucleus (VMH) neurons by microinjection of the excitatory amino acid glutamate sharply increased interscapular brown adipose tissue (IBAT) and core temperatures in urethane-anaesthetized rats. This effect was blocked by co-injection of insulin (0.1-1 microgram) though not an inactive insulin analog, TNB3(More)
Whole body vibration (WBV) may enhance muscular strength and power but little is known about its influence on sensory-motor function. Vibration of a single muscle or tendon affects the afferent system in a manner that depends on amplitude and frequency. WBV stimulates many muscle groups simultaneously and the frequencies and amplitudes used are different(More)
Thyrotropin-releasing hormone (TRH) has diverse effects on body temperature in rodents, but the effector mechanisms that mediate its thermoregulatory actions are not well defined. In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown(More)
We are an ageing society, with falling birth rates and increasing life expectancy. However healthy life span is not keeping pace and on average older adults can expect to be unwell for the last decade of life. Many factors influence both lifespan and healthspan but in humans one of the key factors is likely to be increasing physical inactivity. To separate(More)
Whilst exercise is beneficial to those suffering from low back pain (LBP), spinal shrinkage and vibration during walking may aggravate the condition. This study investigates the effects of spinal unloading, by means of body-weight unloading (BWU), on spinal length and vibration response. Under-arm partial BWU (40% of bodyweight) was performed on 8 healthy(More)
  • 1