Ross McGuire

1Theo H. van Dijk
1Aldo Grefhorst
1Marie-José C. van Lierop
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The past decade has witnessed a paradigm shift in preclinical drug discovery with structure-based drug design (SBDD) making a comeback while high-throughput screening (HTS) methods have continued to generate disappointing results. There is a deficit of information between identified hits and the many criteria that must be fulfilled in parallel to convert(More)
  • Marie-José C. van Lierop, Wynand Alkema, Anke J. Laskewitz, Rein Dijkema, Hans M. van der Maaden, Martin J. Smit +19 others
  • 2012
Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal Glucocorticoid Receptor (GR)-selective compound (Org(More)
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