CONTEXT
Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain.
OBJECTIVE
To assess the major… (More)
CONTEXT
Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain.
OBJECTIVE
To assess the effects on… (More)
We conducted a three-stage genome-wide association study (GWAS) of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. In stage 1, we… (More)
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were… (More)
BACKGROUND
The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal.
METHODS
We recruited 36,282… (More)
CONTEXT
The timing of initiation of hormone therapy may influence its effect on cardiovascular disease.
OBJECTIVE
To explore whether the effects of hormone therapy on risk of cardiovascular disease… (More)
Genome-wide association studies (GWAS) have successfully identified susceptibility loci from marginal association analysis of SNPs. Valuable insight into genetic variation underlying complex diseases… (More)
IMPORTANCE
Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.
OBJECTIVE
To report a comprehensive, integrated… (More)
BACKGROUND
Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is… (More)
BACKGROUND
The lower breast cancer incidence in minority women and the higher breast cancer mortality in African American women than in white women are largely unexplained. The influence of breast… (More)