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Traumatic brain injury (TBI) modulates several cell signaling pathways in the hippocampus critical for memory formation. Previous studies have found that the cAMP-protein kinase A signaling pathway is downregulated after TBI and that treatment with a phosphodiesterase (PDE) 4 inhibitor rolipram rescues the decrease in cAMP. In the present study, we examined(More)
There are conflicting findings about the sexual effects of REM sleep deprivation (REMd). Otherwise, several studies show a dopaminergic hypersensitivity after REMd. The effect of REMd and amantadine (AMA) was studied for standard measures and temporal patterning in the first experiment, in four groups: normal with vehicle, normal with AMA (5.0 and 10(More)
The effects of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan, with or without MAO inhibitors) and of agonists (quipazine and 5-methoxy-N,N-dimethyltryptamine-MeO-DMT) were studied in 3 day REM-deprived or control rats, by recording the presence of the serotonin syndrome and the number of head shakes. The REM sleep-deprived rats showed a(More)
The effects of amantadine on sexual behavior, penile erection, and seminal emission of male rats was studied. Amantadine significantly decreased latency of mounts in all doses (1.25 to 50 mg/kg), and decreased the number of mounts and intromission latency at the highest doses used. The lowest dose of amantadine significantly increased ejaculation latency(More)
Red tears (chromodacryorrhea) in rats are due to porphyrin pigments secreted by Harder's glands and are believed to involve muscarinic mechanisms. Chromodacryorrhea was observed in rats treated with pilocarpine, oxotremorine and neostigmine and this response was blocked by anticholinergic drugs. However, in rats deprived of rapid eye movement (REM) sleep(More)
Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens. The T3 antagonized oxotremorine-induced hypothermia and failed to antagonize eserine hypothermic effect, but potentiated oxotremorine- and eserine-induced tremors. Acetylcholinesterase activity was not altered in T3 rats. The hypothetical(More)
The present work studied the effects of REM sleep deprivation on the responses to cholinomimetic drugs in rats. Cataleptic behavior induced by pilocarpine, oxotremorine and eserine was not modified by previous REM sleep deprivation. On the other hand, the intensity of oxotremorine- and eserine-induced tremors, but not that of pilocarpine, was clearly(More)
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