Rosine Haguenauer - Tsapis

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Gamma-Glutamyltransferase activity was detected in the plasma membrane of the highly differentiated hepatoma cell line Fao, (0.93 mU/mg cell protein). Dexamethasone (1 microM) provoked a 2-3-fold increase in the activity of the enzyme in the presence of fetal calf serum. Maximal induction occurred 48-72 h after addition of the glucocorticoid to the cell(More)
Degradation of many eukaryotic proteins requires their prior modification by conjugation with ubiquitin (Ub). Ub molecules are transferred to lysine residues of target proteins via an E1E2-E3 enzyme thioester cascade (Ub-activating enzyme/Ubconjugating enzyme/Ub-protein ligase) (Ciechanover, 1994). Ubiquitination is known mainly as a signal targeting(More)
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