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Repurposing metformin: an old drug with new tricks in its binding pockets
The present review provides a thorough and detailed account of the current understanding of the molecular pharmacology and signalling mechanisms underlying biguanide–protein interactions and focuses on the key role of the microbiota in regulating age-associated morbidities and a potential role for metformin to modulate its function.
Anthranilate Fluorescence Marks a Calcium-Propagated Necrotic Wave That Promotes Organismal Death in C. elegans
Death of the nematode Caenorhabditis elegans involves a conserved necrotic cell death cascade which generates endogenous blue anthranilate fluorescence, allowing death to be visualized.
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
The Role of the Microbiome in Drug Response.
- Rosina E. Pryor, D. Martínez-Martínez, Leonor M. Quintaneiro, F. Cabreiro
- BiologyAnnual review of pharmacology and toxicology
- 8 January 2020
The current evidence that supports a role for the microbiota as a contributor to both the therapeutic benefits and side effects of drugs, with a particular focus on those used to treat mental disorders, type 2 diabetes, and cancer is outlined.
Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans
- Clara L. Essmann, D. Martínez-Martínez, F. Cabreiro
- Biology, MedicineNature Communications
- 25 February 2020
The data support the view that prolonged lifespan does not always coincide with extended healthspan and AFM provides a highly sensitive technique to measure organismal biomechanical fitness and delivers an approach to screen for health- improving conditions, an essential step towards healthy ageing.
Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death