Roshan Prizak

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1. Phenotypes are often environmentally dependent, which requires organisms to track environmental change. The challenge for organisms is to construct phenotypes using the most accurate environmental cue. 2. Here, we use a quantitative genetic model of adaptation by additive genetic variance, within-and transgenerational plasticity via linear reaction norms(More)
The Rock-Paper-Scissors(RPS) game is a paradigmatic model for cyclic dominance in biological systems. Here we consider this game in the social context of competition between opinions in a networked society. In our model, every agent has an opinion which is drawn from the three choices: rock, paper or scissors. In every timestep a link is selected randomly(More)
Transgenerational effects are broader than only parental relationships. Despite mounting evidence that multigenerational effects alter phenotypic and life-history traits, our understanding of how they combine to determine fitness is not well developed because of the added complexity necessary to study them. Here, we derive a quantitative genetic model of(More)
Gene regulation relies on the specificity of transcription factor (TF)-DNA interactions. Limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF-DNA interactions or remains erroneously inactive. As each TF can have numerous interactions with noncognate cis-regulatory elements,(More)
Regulatory networks consist of interacting molecules with a high degree of mutual chemical specificity. How can these molecules evolve when their function depends on maintenance of interactions with cognate partners and simultaneous avoidance of deleterious " crosstalk " with noncognate molecules? Although physical models of molecular interactions provide a(More)
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