Roshan Dadachanji

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OBJECTIVE To investigate the association of paraoxonase 1 (PON1) polymorphisms (L55M and Q192R) with polycystic ovary syndrome (PCOS) susceptibility and its related traits in Indian women. DESIGN Case-control study. SETTING Academic research institute, infertility, and endocrinology clinics. PATIENT(S) Controls (n = 326), women with PCOS (n = 482). (More)
BACKGROUND Insulin-like factor 3 (INSL3), secreted by the ovarian theca cells is involved in androgen production, follicular growth and oocyte maturation. Both androgens and INSL3 levels are reported to be elevated in women with polycystic ovary syndrome (PCOS), indicating that INSL3 could contribute to PCOS etiology. This case-control association study(More)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder which affects women in their childbearing years, characterized by chronic anovulation, hyperandrogenemia, hyperinsulinemia and obesity. It is frequently associated with an increased risk for insulin resistance with long term health implications like type 2 diabetes mellitus and atherosclerosis(More)
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