Rosemary Holt

Learn More
Siblings of individuals with autism have over 20 times the population risk of autism. Evidence of comparable, but less marked, cognitive and social communication deficits in siblings suggests a role for these traits in the search for biomarkers of familial risk. However, no neuroimaging biomarkers of familial risk have been identified to date. Here we show,(More)
Cryptococcus gattii recently emerged as the causative agent of cryptococcosis in healthy individuals in western North America, despite previous characterization of the fungus as a pathogen in tropical or subtropical regions. As a foundation to study the genetics of virulence in this pathogen, we sequenced the genomes of a strain (WM276) representing the(More)
The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and the unaffected siblings of ASC individuals. In this work, we used a multivariate methodology applied on(More)
BACKGROUND Mentalizing deficits are a hallmark of the autism spectrum condition (ASC) and a potential endophenotype for atypical social cognition in ASC. Differences in performance and neural activation on the 'Reading the Mind in the Eyes' task (the Eyes task) have been identified in individuals with ASC in previous studies. METHOD Performance on the(More)
The "Reading the Mind in the Eyes" test (Eyes test) is an advanced test of theory of mind. Typical sex difference has been reported (i.e., female advantage). Individuals with autism show more difficulty than do typically developing individuals, yet it remains unclear how this is modulated by sex, as females with autism have been under-represented. Here in a(More)
Atypical activation during the Embedded Figures Task has been demonstrated in autism, but has not been investigated in siblings or related to measures of clinical severity. We identified atypical activation during the Embedded Figures Task in participants with autism and unaffected siblings compared with control subjects in a number of temporal and frontal(More)
UNLABELLED BACKGROUND Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mode network (DMN) in first-degree relatives of those with autism (such as siblings) and it is not known whether atypical(More)
This paper describes the silicon microstrip modules in the barrel section of the SemiConductor Tracker (SCT) of the ATLAS experiment at the CERN Large Hadron Collider (LHC). The module requirements, components and assembly techniques are given, as well as first results of the module performance on the fully-assembled barrels that make up the detector being(More)
We propose to measure the Beam Spin Asymmetry (BSA) in Deeply Virtual Compton Scattering (DVCS) off 4He. The measurements will use a 6 GeV polarized electron beam, a 4He pressurized gas target, the CLAS and the BoNuS RTPC detectors. The major goal of this proposal is to perform the first fully quantitative investigation of the DVCS reaction off a nuclear(More)
E. C. Schulte, A. Afanasev, M. Amarian, K. Aniol, S. Becher, K. Benslama, L. Bimbot, P. Bosted, E. Brash, J. Calarco, Z. Chai, C. Chang, T. Chang, J. P. Chen, S. Choi, E. Chudakov, S. Churchwell, D. Crovelli, S. Dieterich, S. Dumalski, D. Dutta, M. Epstein, K. Fissum, B. Fox, S. Frullani, H. Gao, J. Gao, F. Garibaldi, O. Gayou, R. Gilman, A. Glamazdin, C.(More)